Enorme estudo Canadense demonstra que
O transtorno por uso de álcool (AUD) está associado a envelhecimento acelerado do cérebro.
Estudos de neuroimagem mostram redução de volume cerebral, especialmente em:
-cerebelo
-substância branca frontal
-hipocampo
O álcool pode aumentar risco de demência e piorar processos normais do envelhecimento cerebral.
Parte dessas alterações pode melhorar com abstinência prolongada, mas nem sempre completamente.
https://www.sciencedirect.com/science/article/abs/pii/S074183292200060XA multi-national, longitudinal cohort study followed 131 415 participants, age 18–77 years at baseline, who were alcohol drinkers and dementia-free. At follow-up, 12–30 years later, 0.8% had developed dementia. Remarkably, 10.4% of the nearly 100 000 participants with data on loss of consciousness reported loss of consciousness due to excessive alcohol consumption. Relative to moderate drinkers, heavy drinkers had a 1.2-fold greater risk of developing dementia. Regardless of typical weekly alcohol consumption, men and women who reported having loss of consciousness in the previous 12 months had a 2-fold increase in dementia risk (Kivimäki et al., 2020). This finding raises serious caution for drinkers whose aim is to "drink to oblivion” (Hingson & White, 2013; Labhart, Livingston, Engels, & Kuntsche, 2018). One might extrapolate this finding to youth who engage in "intense binge drinking” to achieve unconsciousness, an activity that may initiate an insidious neurodegenerating process, or alternatively, may leave an early neural "scar” that could be reinstated with age-related degeneration.
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