Exercício pode diminuir a chance de ter cancer de mama!
comentada em 02/07/2023 08:43

Exercise Can Help Reduce Breast Cancer
During muscle contractions, the muscle releases some factors that kill, or at least decrease the growth, of neoplastic cells and in some cases may play a role in fighting breast cancer.



It is believed that the risk of breast cancer is decreased with exercise because exercise slows the growth of abnormal cells and that precancerous cells can be destroyed by the body before they start to develop.
Artigo original

Frontiers | Myokines derived from contracting skeletal muscle suppress anabolism in MCF7 breast cancer cells by inhibiting mTOR

In summary, we demonstrate that the protective benefits of exercise against breast cancer can be attributed, at least in part, to myokines released by contracting skeletal muscle, independent of any hormonal or whole-body effects of regular physical activity. These myokines suppressed cancer growth independent of whether they were derived from the muscles of a sedentary or active animal, indicating that the release of anti-cancer myokines is an inherent property of muscular contraction. These compounds act on the anabolic mTOR axis of the cancer cell, suppressing protein synthesis and rescuing the endogenous inhibitor DEPTOR. We recognize that there are numerous forms of breast cancers in clinical populations and understand the importance of conducting similar studies across that spectrum to further validate the findings in this study. Ongoing experiments in our laboratory are devoted to pursuing the identity of which specific molecules responsible for mediating this effect, the exact nature of their release from the muscle, and how they are taken up by cancerous cells of the breast. Taken together, we believe that further investigation of the relationship between skeletal muscle, myokines, and breast cancer will provide exciting novel outcomes, and pave the way for clinical advances in the understanding and treatment of malignant tumors.